We have published work in diverse areas of cancer, ulcerative colitis, metabolic diseases, and aging. Check out a few of our recent publications below.
Complete List of Published Work can be found in the link below
NAD+ flux is maintained in aged mice despite lower tissue concentrations
In this paper, we used stable isotope tracing technique to address the long-debated question of how NAD levels decline during aging. We found that NAD synthesis and flux is maintained in aged mice, despite lower steady-state concentrations. We established that an increase in the activity of NAD-consuming enzymes leads to an age-related decline in NAD.
The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms
In this paper, we investigate the potential of a phytochemical celastrol to slow aging processes. Our findings suggest that the circadian timing of celastrol delivery impacts behavioral rhythm in aged mice.