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Our Publications

We have published work in diverse areas of cancer, ulcerative colitis, metabolic diseases, and aging. Check out a few of our recent publications below. 

Complete List of Published Work can be found in the link below

https://www.ncbi.nlm.nih.gov/myncbi/1DSLex7dmcfwU_/bibliography/public/

NAD+ flux is maintained in aged mice despite lower tissue concentrations

In this paper, we used stable isotope tracing technique to address the long-debated question of how NAD levels decline during aging. We found that NAD synthesis and flux is maintained in aged mice, despite lower steady-state concentrations. We established that an increase in the activity of NAD-consuming enzymes leads to an age-related decline in NAD.

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NAD precursors cycle between host tissues and the gut microbiome

In this work, we addressed a fundamental question of how the gut microbiome make NAD molecules. We made a surprising discovery that the host and the gut microbiome share NAD precursors.

Hypothalamic mTORC2 is essential for metabolic health and longevity

This publication details our study on the role of mTORC2 in hypothalamic neurons. We find that hypothalamic mTORC2 is required to maintain metabolic health in diet-induced obesity and  aging.

The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms

In this paper, we investigate the potential of a phytochemical celastrol to slow aging processes. Our findings suggest that the circadian timing of celastrol delivery impacts behavioral rhythm in aged mice.

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